钙粘蛋白相关家族成员2 (原钙粘蛋白LKC) (PC-LKC) (原钙粘蛋白-24)
钙粘蛋白相关家族成员2 (原钙粘蛋白LKC) (PC-LKC) (原钙粘蛋白-24)
Q9BYE9功能描述
微绒毛间粘附分子，通过其胞外结构域与相邻微绒毛上的CDHR5形成钙依赖性的异嗜性复合物。从而控制上皮细胞顶端膜处微绒毛的排列。通过其胞质结构域，与微绒毛胞质蛋白相互作用，形成微绒毛间粘附复合物/IMAC。该复合物在微绒毛和上皮刷状缘分化中发挥核心作用 (PubMed:24725409)。可能还在上皮细胞的细胞-细胞粘附和接触抑制中发挥作用 (PubMed:12117771)。 {ECO:0000269|PubMed:12117771, ECO:0000269|PubMed:24725409}.
组织特异性
Highly expressed in liver, kidney and colon. Moderately expressed in small intestine. Down-regulated in a number of liver and colon cancers (PubMed:12117771, PubMed:15534908). Expressed in duodenum with higher expression in enterocytes along the villus axis and lower expression in crypts (at protein level) (PubMed:24725409).
亚细胞定位
Apical cell membrane
关键词