含CUB结构域蛋白1 (膜糖蛋白gp140) (减法免疫M plus HEp3相关135 kDa蛋白) (SIMA135) (跨膜并与src激酶相关) (CD抗原CD318)
含CUB结构域蛋白1 (膜糖蛋白gp140) (减法免疫M plus HEp3相关135 kDa蛋白) (SIMA135) (跨膜并与src激酶相关) (CD抗原CD318)
Q9H5V8功能描述
可能参与细胞粘附和细胞基质关联。可能通过其磷酸化在锚定与迁移或增殖与分化的调节中发挥作用。可能是白血病诊断和未成熟造血干细胞亚群的新型标志物。属于参与肿瘤进展和转移的四跨膜蛋白网。 {ECO:0000269|PubMed:11466621, ECO:0000269|PubMed:12799299, ECO:0000269|PubMed:15153610, ECO:0000269|PubMed:16007225, ECO:0000269|PubMed:16404722, ECO:0000269|PubMed:8647901}。
组织特异性
Highly expressed in mitotic cells with low expression during interphase. Detected at highest levels in skeletal muscle and colon with lower levels in kidney, small intestine, placenta and lung. Up-regulated in a number of human tumor cell lines, as well as in colorectal cancer, breast carcinoma and lung cancer. Also expressed in cells with phenotypes reminiscent of mesenchymal stem cells and neural stem cells.
亚细胞定位
[Isoform 1]: Cell membrane
关键词