CDC45 O75419

细胞分裂控制蛋白45同源物 (PORC-PI-1)

蛋白质信息 (UniProt)

细胞分裂控制蛋白45同源物 (PORC-PI-1)

O75419

功能描述

染色体DNA复制起始所必需。CDC45-MCM-GINS (CMG) 解旋酶的核心组分，该分子机器在复制过程中解开模板DNA，复制体围绕其构建。 {ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232}。

组织特异性

Widely expressed, highest levels are found in adult testis and thymus and in fetal liver.

亚细胞定位

Nucleus

关键词

3D-structure Alternative splicing Cell cycle Chromosome Disease variant DNA replication Dwarfism Nucleus Phosphoprotein Proteomics identification

外部链接

UniProt: O75419

NCBI Gene

GeneCards