补体衰变加速因子 (CD抗原 CD55)
补体衰变加速因子 (CD抗原 CD55)
P08174功能描述
该protein识别在C4和c3激活过程中局部生成的新生C4b和C3b与细胞表面羟基或氨基基团缩合而成的C4b和C3b片段。daf与细胞相关C4b和C3b多肽的相互作用干扰了它们催化C2和factor B转化为具有酶活性的C2a和Bb的能力，从而阻止C4b2a和C3bBb（补体级联反应的扩增转化酶）的形成 (PubMed:7525274)。通过去稳定化并阻止C3和C5转化酶的形成来抑制补体激活，从而防止补体损伤 (PubMed:28657829)。 {ECO:0000269|PubMed:7525274, ECO:0000305|PubMed:28657829}.; FUNCTION: (Microbial infection) 作为柯萨奇病毒A21、柯萨奇病毒B1、B3和B5的受体。 {ECO:0000269|PubMed:9151867}.; FUNCTION: (Microbial infection) 作为人类肠道病毒70型和D68型的受体 (Probable)。 {ECO:0000269|PubMed:8764022}.; FUNCTION: (Microbial infection) 作为人类埃可病毒6、7、11、12、20和21型的受体。 {ECO:0000269|PubMed:7525274, ECO:0000305|PubMed:12409401}.
组织特异性
Expressed on the plasma membranes of all cell types that are in intimate contact with plasma complement proteins. It is also found on the surfaces of epithelial cells lining extracellular compartments, and variants of the molecule are present in body fluids and in extracellular matrix.
亚细胞定位
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Lipid-anchor, GPI-anchor.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted
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