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CD320 Q9NPF0

CD320抗原 (8D6抗原) (FDC信号分子8D6) (FDC-SM-8D6) (钴胺传递蛋白受体) (TCblR) (CD抗原CD320)

蛋白质信息 (UniProt)

CD320抗原 (8D6抗原) (FDC信号分子8D6) (FDC-SM-8D6) (钴胺传递蛋白受体) (TCblR) (CD抗原CD320)

Q9NPF0

功能描述

饱和钴胺素转钴胺蛋白(transcobalamin)的受体(TCbl) (PubMed:18779389)。在钴胺素摄取中起重要作用 (PubMed:18779389, PubMed:20524213)。质膜蛋白,表达于滤泡树突状细胞(FDC)并介导与生发中心B细胞的相互作用 (PubMed:10727470)。作为共刺激因子促进B细胞对抗原刺激的反应;促进B细胞分化和增殖 (PubMed:10727470, PubMed:11418631)。生发中心B(GC-B)细胞通过与T细胞和滤泡树突状细胞(FDC)相互作用分化为记忆B细胞和浆细胞(PC) (PubMed:11418631)。CD320增强由IL-10产生的PC前体的增殖 (PubMed:11418631)。 {ECO:0000269|PubMed:10727470, ECO:0000269|PubMed:11418631, ECO:0000269|PubMed:18779389, ECO:0000269|PubMed:20524213}.

组织特异性

Detected in the germinal center (GC) of lymphoid follicles (at protein level) (PubMed:11418631). Expressed abundantly on follicular dendritic cells (FDCs) (PubMed:10727470).

亚细胞定位

Cell membrane

关键词

3D-structure Alternative splicing Calcium Cell membrane Direct protein sequencing Disease variant Disulfide bond Glycoprotein Growth factor Membrane