CD302 Q8IX05

CD302抗原 (C型凝集素BIMLEC) (C型凝集素结构域家族13成员A) (DEC205相关C型凝集素1) (I型跨膜C型凝集素受体DCL-1) (CD抗原CD302)

功能描述

多功能C型凝集素受体，参与内吞、吞噬以及细胞粘附和迁移的调节 (PubMed:17947679, PubMed:27316686)。在引导树突状细胞至淋巴结中起关键作用 (PubMed:27316686)。亦作为丙型肝炎病毒 (HCV) 在肝细胞表面的限制因子起作用，可能是通过抑制病毒细胞进入步骤 (PubMed:35297672)。 {ECO:0000269|PubMed:17947679, ECO:0000269|PubMed:27316686, ECO:0000269|PubMed:35297672}。

组织特异性

Expressed at moderate levels in monocytes, myeloid blood dendritic cells and granulocytes and at low levels in plasmacytoid blood dendritic cells, monocyte-derived macrophages and monocyte-derived dendritic cells, with no expression detected in T-lymphocytes, B-lymphocytes and natural killer cells (at protein level). Expressed widely in different tissues, with highest expression levels in liver, lung, peripheral blood leukocytes and spleen, and lowest levels in neuronal tissues, skeletal muscle and ovary. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells.

亚细胞定位

Cell membrane