CD248 Q9HCU0

内唾液酸蛋白（肿瘤内皮标志物1）（CD抗原CD248）

功能描述

参与多种生物学过程的细胞表面糖蛋白，包括血管生成、免疫应答调节以及组织重塑和修复。通过对PDGF受体信号通路的正向调节参与周细胞增殖 (PubMed:20484976)。作为因子X的支架，触发变构变化和因子X与TF-因子VIIa复合物的空间重排，从而增强凝血激活。通过与胰岛素受体/INSR相互作用并降低其响应胰岛素的自磷酸化能力来调节胰岛素信号通路。还通过促进促炎细胞因子的产生来调节巨噬细胞中LPS诱导的炎症反应。在人类中，与基质细胞中促进增殖的作用相反，它负向调节T细胞增殖 (PubMed:21466550)。 {ECO:0000250|UniProtKB:Q91V98, ECO:0000269|PubMed:15862292, ECO:0000269|PubMed:20484976, ECO:0000269|PubMed:21466550, ECO:0000269|PubMed:28671670}.

组织特异性

Expressed in tumor endothelial cells but absent or barely detectable in normal endothelial cells. Expressed in metastatic lesions of the liver and during angiogenesis of corpus luteum formation and wound healing. Expressed in vascular endothelial cells of malignant tumors but not in normal blood vessels. Expressed in stromal fibroblasts. Strongly expressed in pericytes (PubMed:20484976). Expressed on stromal cells and cells with lymphoid morphology such a T-cells (PubMed:21466550).

亚细胞定位

Membrane