CD200R1 Q8TD46

细胞表面糖蛋白CD200受体1 (CD200细胞表面糖蛋白受体) (细胞表面糖蛋白OX2受体1)

功能描述

CD200/OX2细胞表面糖蛋白的抑制性受体。通过抑制选定刺激下促炎分子（包括TNF、干扰素和诱导型一氧化氮合酶(iNOS)）的表达来限制炎症。亦以与宿主CD200相同的亲和力和动力学结合HHV-8 K14病毒CD200同源物。 {ECO:0000269|PubMed:12960329}。

组织特异性

Expressed in granulocytes, monocytes, most T-cells, neutrophils, basophils and a subset of NK, NKT and B-cells (at protein level). Expressed in bone marrow, lymph nodes, spleen, lung, liver, spinal cord, kidney. Expressed in monocyte-derived dendritic and mast cells.

亚细胞定位

[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted.