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CD1E P15812

T细胞表面糖蛋白CD1e,膜相关 (hCD1e) (R2G1) (CD抗原CD1e) [裂解为:T细胞表面糖蛋白CD1e,可溶性 (sCD1e)]

蛋白质信息 (UniProt)

T细胞表面糖蛋白CD1e,膜相关 (hCD1e) (R2G1) (CD抗原CD1e) [裂解为:T细胞表面糖蛋白CD1e,可溶性 (sCD1e)]

P15812

功能描述

T细胞表面糖蛋白CD1e,可溶形式结合二酰化脂质,包括磷脂酰肌醇和二酰化磺基糖脂,且是细胞表面糖脂抗原呈递所必需的。膜结合形式无活性。{ECO:0000269|PubMed:10948205, ECO:0000269|PubMed:16311334, ECO:0000269|PubMed:21788486}。

组织特异性

Expressed on cortical thymocytes, dendritic cells, Langerhans cells, on certain T-cell leukemias, and in various other tissues.

亚细胞定位

[T-cell surface glycoprotein CD1e, membrane-associated]: Golgi apparatus membrane; Single-pass type I membrane protein. Early endosome. Late endosome. Note=Predominantly localized in the trans-Golgi network in immature dendritic cells, and as a cleaved, soluble protein in the lysosome lumen of mature dendritic cells.; SUBCELLULAR LOCATION: [T-cell surface glycoprotein CD1e, soluble]: Lysosome lumen.

关键词

3D-structure Adaptive immunity Alternative splicing Disulfide bond Endosome Glycoprotein Golgi apparatus Immunity Immunoglobulin domain Lipid-binding