免疫球蛋白超家族成员2 (IgSF2) (细胞表面糖蛋白V7) (含Glu-Trp-Ile EWI基序蛋白101) (EWI-101) (CD抗原CD101)
免疫球蛋白超家族成员2 (IgSF2) (细胞表面糖蛋白V7) (含Glu-Trp-Ile EWI基序蛋白101) (EWI-101) (CD抗原CD101)
Q93033功能描述
作为CD3诱导的T细胞增殖的抑制剂发挥作用。抑制活化T细胞上IL2RA的表达和IL2的分泌。抑制IL2产生和细胞增殖所需的酪氨酸激酶。抑制磷脂酶C-gamma-1/PLCG1磷酸化以及随后CD3诱导的细胞内游离钙变化。阻止活化T细胞核因子向细胞核的易位。通过皮肤树突状细胞分泌IL10，在抑制T细胞增殖中发挥作用。可能是CD4(+) CD56(+)白血病肿瘤细胞的标志物。 {ECO:0000269|PubMed:11093127, ECO:0000269|PubMed:15737213, ECO:0000269|PubMed:7722299, ECO:0000269|PubMed:9233604, ECO:0000269|PubMed:9389317, ECO:0000269|PubMed:9647226}.
组织特异性
Expressed in lung, thymus and small intestine. Detected in cutaneous dendritic cells, activated T-cells, monocytes and granulocytes as well as with epithelial cells with dendritic morphology. Expressed in some leukemic cells, the CD4(+) CD56(+) blastic tumor cells, as well as in Langerhans cells from LCH (Langerhans cell histiocytosis) patients.
亚细胞定位
Membrane
关键词