CCRL2 O00421

C-C趋化因子受体样2 (趋化因子受体CCR11) (趋化因子X) (推定MCP-1趋化因子受体)

功能描述

CCL19和chemerin/RARRES2的受体。似乎不是信号受体，但可能通过捕获和内化CCL19或通过将RARRES2配体呈递给功能性信号受体CMKLR1，在调节趋化因子触发的免疫反应中发挥作用。对Th2反应的发育起关键作用。

组织特异性

Expressed abundantly in immunal tissues such as spleen, fetal liver, lymph node and bone marrow. Strong expression also in lung and heart. Expressed in almost all hematopoietic cells including monocytes, macrophages, PMNs, T-cells (both CD4+ and CD8+), monocyte-derived iDCs, NK cells, and CD34+ progenitor cells. B-cells expressed isoform 1 but not isoform 2. Up-regulated on synovial neutrophils of rheumatoid arthritis patients.

亚细胞定位

Cell membrane