CCR4 P51679

C-C趋化因子受体4型 (C-C CKR-4) (CC-CKR-4) (CCR-4) (CCR4) (K5-5) (CD抗原 CD194)

功能描述

C-C型趋化因子CCL17/TARC、CCL22/MDC和CKLF异构体1/CKLF1的高亲和力受体。该受体的活性由G(i)蛋白介导，G(i)蛋白激活磷脂酰肌醇-钙第二信使系统。可作为循环记忆淋巴细胞上的趋化归巢受体，并作为某些原发性HIV-2分离株的共受体。在中枢神经系统（CNS）中，可能介导海马神经元的存活。 {ECO:0000269|PubMed:10466728, ECO:0000269|PubMed:10754297, ECO:0000269|PubMed:16137713, ECO:0000269|PubMed:9169480, ECO:0000269|PubMed:9430724}.

组织特异性

Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes (PubMed:10754297, PubMed:9169480). Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells (PubMed:10754297).

亚细胞定位

Cell membrane; Multi-pass membrane protein.