CCNDBP1 O95273

细胞周期蛋白D1结合蛋白1 (Grap2和细胞周期蛋白D相互作用蛋白) (Maid人源同源物)

功能描述

可能负向调节细胞周期进程。可能至少部分通过抑制cyclin-D1/CDK4复合物发挥作用，从而阻止RB1的磷酸化并阻断E2F依赖的转录。 {ECO:0000269|PubMed:10801854}。

组织特异性

Ubiquitously expressed. Expression is down-regulated in a variety of tumor types including breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas.

亚细胞定位

Cytoplasm. Nucleus.