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CCL8 P80075

C-C基序趋化因子8 (HC14) (单核细胞趋化蛋白2) (单核细胞趋化蛋白2) (MCP-2) (小诱导细胞因子A8) [剪切为: MCP-2(6-76)]

蛋白质信息 (UniProt)

C-C基序趋化因子8 (HC14) (单核细胞趋化蛋白2) (单核细胞趋化蛋白2) (MCP-2) (小诱导细胞因子A8) [剪切为: MCP-2(6-76)]

P80075

功能描述

趋化因子,吸引单核细胞、淋巴细胞、嗜碱性粒细胞和嗜酸性粒细胞。可能在肿瘤发生和炎症宿主反应中起作用。该蛋白能结合肝素。加工形式MCP-2(6-76)不显示单核细胞趋化活性,但抑制CCL7的趋化作用,同时也抑制CCL2、CCL5和CCL8的趋化作用。 {ECO:0000269|PubMed:9558113}。

组织特异性

Highest expression found in the small intestine and peripheral blood cells. Intermediate levels seen in the heart, placenta, lung, skeletal muscle, thymus, colon, ovary, spinal cord and pancreas. Low levels seen in the brain, liver, spleen and prostate.

亚细胞定位

Secreted.

关键词

3D-structure Chemotaxis Cytokine Direct protein sequencing Disulfide bond Heparin-binding Inflammatory response Proteomics identification Pyrrolidone carboxylic acid Reference proteome