C-C基序趋化因子22 (CC趋化因子STCP-1) (MDC(1-69)) (巨噬细胞衍生趋化因子) (小诱导细胞因子A22) (受刺激T细胞趋化蛋白1) [切割为：MDC(3-69); MDC(5-69); MDC(7-69)]
C-C基序趋化因子22 (CC趋化因子STCP-1) (MDC(1-69)) (巨噬细胞衍生趋化因子) (小诱导细胞因子A22) (受刺激T细胞趋化蛋白1) [切割为：MDC(3-69); MDC(5-69); MDC(7-69)]
O00626功能描述
可能在活化的/效应T淋巴细胞向炎症部位的迁移及活化的T淋巴细胞生理学的其他方面发挥作用。对单核细胞、树突状细胞和自然杀伤细胞具有趋化作用。对原代活化的T淋巴细胞是弱趋化因子，对慢性活化的T淋巴细胞是强趋化因子，但对中性粒细胞、嗜酸性粒细胞和静息T淋巴细胞无趋化活性。与CCR4结合。加工形式MDC(3-69)、MDC(5-69)和MDC(7-69)似乎无活性。
组织特异性
Highly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. Also found in lymph node, appendix, activated monocytes, resting and activated macrophages. Lower expression in lung and spleen. Very weak expression in small intestine. In lymph node expressed in a mature subset of Langerhans' cells (CD1a+ and CD83+). Expressed in Langerhans' cell histiocytosis but not in dermatopathic lymphadenopathy. Expressed in atopic dermatitis, allergic contact dermatitis skin, and psoriasis, in both the epidermis and dermis.
亚细胞定位
Secreted.
关键词