CCDC62 Q6P9F0

含卷曲螺旋结构域蛋白62 (Protein TSP-NY) (Protein aaa)

功能描述

核受体共激活因子，能够优先增强雌激素受体ESR1和ESR2的反式激活。也能调节孕酮/PGR、糖皮质激素/NR3C1和雄激素/AR受体的反式激活，尽管水平较低；对维生素D受体/VDR影响很小。为正常精子形成所必需。其可能在顶体形成中发挥作用(By similarity)。{ECO:0000250|UniProtKB:E9PVD1, ECO:0000269|PubMed:19126643}。

组织特异性

Highly expressed in adult testis. Expressed in both prostate epithelial and stromal cells, with predominant expression in epithelial cells (at protein level) (PubMed:19126643). Not detected in prostate by RT-PCR (PubMed:19165854). Overexpressed in various cancers.

亚细胞定位

Cytoplasm