CCDC134 Q9H6E4

含卷曲螺旋结构域蛋白134

功能描述

防止HSP90B1蛋白过度糖基化所需的分子适配体：在翻译过程中，与新生HSP90B1及OST-A复合物的STT3A催化组分结合，并将它们连接到一个专门的易位子，该易位子为HSP90B1折叠形成微环境 (PubMed:38670073, PubMed:39509507)。在含CCDC134的易位子中，STT3A与HSP90B1的SRT假底物基序结合，在折叠完成前阻止其进入兼性糖基化位点，从而防止HSP90B1的过度糖基化及随后的降解 (PubMed:39509507)。在细胞外分泌形式中，促进CD8(+) T细胞的增殖和活化，提示其具有细胞因子样功能 (PubMed:25125657)。可能抑制ERK和JNK信号活性 (PubMed:18087676, PubMed:23070808)。可能通过其对ERK和JNK信号的作用抑制细胞迁移和侵袭活性 (PubMed:23070808)。也可能定位于细胞核：增强PCAF组蛋白乙酰转移酶 (HAT) 复合物成员TADA2A的稳定性，从而促进PCAF介导的组蛋白乙酰转移酶活性 (PubMed:22644376)。在骨发生和骨发育的调节中起关键作用 (PubMed:32181939)。 {ECO:0000269|PubMed:18087676, ECO:0000269|PubMed:22644376, ECO:0000269|PubMed:23070808, ECO:0000269|PubMed:25125657, ECO:0000269|PubMed:32181939, ECO:0000269|PubMed:38670073, ECO:0000269|PubMed:39509507}。

组织特异性

Expressed in cervical gland, cervical squamous epithelium, endometrium, stomach, kidney distal convoluted tubule, spermatogenic cells in testis, mammary gland, liver and striated muscle (at protein level) (PubMed:18087676, PubMed:23070808). Also detected in placenta (PubMed:18087676). Highest expression in testis relative to other tissues (PubMed:18087676). Detected in T cells and dendritic cells; highly expressed in activated CD8(+) T cells, and also expressed at lower levels in CD4(+) T cells (PubMed:25125657).

亚细胞定位

Endoplasmic reticulum lumen