CBY1 Q9Y3M2

Chibby同源蛋白1 (ARPP结合蛋白) (胞质富含亮氨酸蛋白) (PIGEA-14) (PKD2相互作用蛋白，高尔基体和内质网相关蛋白1)

功能描述

通过结合CTNNB1/β-catenin并与TCF/LEF转录因子竞争从而抑制beta-catenin介导的转录激活，进而抑制Wnt/Wingless通路 (PubMed:12712206, PubMed:19435523)。也被证明在调节多囊蛋白-2/PKD2及可能其他细胞内蛋白的细胞内转运中发挥作用 (PubMed:15194699)。促进脂肪细胞和心肌细胞分化 (By similarity)。 {ECO:0000250|UniProtKB:Q9D1C2, ECO:0000269|PubMed:12712206, ECO:0000269|PubMed:15194699, ECO:0000269|PubMed:19435523}。

组织特异性

Widely expressed. Expressed at higher levels in heart, skeletal muscle, kidney and placenta. Also found in brain, lung, liver and testis. Significantly down-regulated in thyroid and metastatic uterine tumors.

亚细胞定位

Nucleus speckle