E3泛素蛋白连接酶CBL-B (EC 2.3.2.27) (Casitas B系淋巴瘤原癌基因b) (环指蛋白56) (RING型E3泛素转移酶CBL-B) (SH3结合蛋白CBL-B) (信号转导蛋白CBL-B)
E3泛素蛋白连接酶CBL-B (EC 2.3.2.27) (Casitas B系淋巴瘤原癌基因b) (环指蛋白56) (RING型E3泛素转移酶CBL-B) (SH3结合蛋白CBL-B) (信号转导蛋白CBL-B)
Q13191功能描述
E3泛素-protein连接酶，从特定的E2泛素结合酶接受泛素，并将其转移到底物，通常促进proteasome对其降解 (PubMed:20525694, PubMed:40101708)。负向调节TCR (T-cell receptor)、BCR (B-cell receptor)和FCER1 (高亲和力免疫球蛋白epsilon受体)信号转导通路 (PubMed:40101708)。在初始T细胞中，抑制TCR接合后的VAV1激活，并强制要求CD28共刺激以进行增殖和IL-2产生 (By similarity)。还通过促进PIK3R1/p85泛素化发挥作用，这会削弱其向TCR的募集及随后的激活 (PubMed:11087752, PubMed:11526404)。在活化的T细胞中，抑制再刺激时的PLCG1激活和钙动员，并促进无能状态 (By similarity)。参与LAG3介导的TCR信号抑制：在配体结合LAG3后，催化LAG3的'Lys-63'连接泛素化，释放LAG3 C末端使其脱离细胞膜，并启动阻止TCR激活的信号 (PubMed:39030301, PubMed:40101708)。在B细胞中，通过泛素化SYK并促进其proteasomal降解发挥作用 (By similarity)。微弱促进SRC泛素化 (PubMed:14661060)。可能参与EGFR泛素化和内吞 (PubMed:10086340)。可能与E2泛素-protein连接酶UB2D3功能偶联。与CBL结合，通过PDGFRA的泛素化和内吞，正确反馈抑制纤毛血小板源性生长因子受体-alpha (PDGFRA)信号通路所必需 (By similarity)。 {ECO:0000250|UniProtKB:Q3TTA7, ECO:0000269|PubMed:10022120, ECO:0000269|PubMed:10086340, ECO:0000269|PubMed:11087752, ECO:0000269|PubMed:11526404, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:20525694, ECO:0000269|PubMed:39030301, ECO:0000269|PubMed:40101708}.
组织特异性
Expressed in placenta, heart, lung, kidney, spleen, ovary and testis, as well as fetal brain and liver and hematopoietic cell lines, but not in adult brain, liver, pancreas, salivary gland, or skeletal muscle. Present in lymphocytes (at protein level).
亚细胞定位
Cytoplasm
关键词