CALCRL Q16602

降钙素基因相关肽1型受体 (CGRP 1型受体) (降钙素受体样受体) (CRLR)

蛋白质信息 (UniProt)

降钙素基因相关肽1型受体 (CGRP 1型受体) (降钙素受体样受体) (CRLR)

Q16602

功能描述

G protein-coupled receptor，其特异性由其与receptor-activity-modifying proteins (RAMPs)的相互作用决定 (PubMed:32296767, PubMed:33602864, PubMed:8626685)。与RAMP1共同形成calcitonin-gene-related peptides CALCA/CGRP1和CALCB/CGRP2的受体复合物 (PubMed:33602864)。与RAMP2或RAMP3共同作为adrenomedullin (ADM和ADM2)的受体复合物发挥功能 (PubMed:32296767, PubMed:9620797)。配体结合引起构象变化，通过guanine nucleotide-binding proteins (G proteins)触发信号传导并调节下游效应因子的活性。激活cAMP依赖途径 (PubMed:32296767, PubMed:8626685)。 {ECO:0000269|PubMed:32296767, ECO:0000269|PubMed:33602864, ECO:0000269|PubMed:8626685, ECO:0000269|PubMed:9620797}。

组织特异性

Predominantly expressed in the lung and heart.

亚细胞定位

Cell membrane

关键词

3D-structure Cell membrane Direct protein sequencing Disease variant Disulfide bond G-protein coupled receptor Glycoprotein Membrane Phosphoprotein Proteomics identification

外部链接

UniProt: Q16602

NCBI Gene

GeneCards