CACNA1H O95180

电压依赖性T型钙通道亚基alpha-1H (低电压激活钙通道alpha1 3.2亚基) (电压门控钙通道亚基alpha Cav3.2)

功能描述

产生T型钙电流的电压敏感钙通道。T型钙通道属于“低电压激活(LVA)”组。此类通道的一个特点是在相当负的电位下开放，并具有电压依赖性失活 (PubMed:27149520, PubMed:9670923, PubMed:9930755)。T型通道在中枢神经元和心脏起搏细胞中起起搏功能，并支持分泌细胞和血管平滑肌中的钙信号传导 (Probable)。它们也可能参与神经元放电模式的调节 (PubMed:15048902)。在肾上腺球状带中，参与响应AGT/血管紧张素II或高钾血症的醛固酮生成信号通路 (PubMed:25907736, PubMed:27729216)。 {ECO:0000269|PubMed:24277868, ECO:0000269|PubMed:25907736, ECO:0000269|PubMed:27149520, ECO:0000269|PubMed:27729216, ECO:0000269|PubMed:9670923, ECO:0000269|PubMed:9930755, ECO:0000305, ECO:0000305|PubMed:15048902}。

组织特异性

Expressed in the adrenal glomerulosa (at protein level) (PubMed:25907736, PubMed:27729216). In nonneuronal tissues, the highest expression levels are found in the kidney, liver, and heart. In the brain, most abundant in the amygdala, caudate nucleus, and putamen (PubMed:9670923, PubMed:9930755). In the heart, expressed in blood vessels.

亚细胞定位

Cell membrane