钙结合蛋白1 (CaBP1) (Calbrain) (Caldendrin)
钙结合蛋白1 (CaBP1) (Calbrain) (Caldendrin)
Q9NZU7功能描述
调节肌醇1,4,5-三磷酸受体(ITPRs)的钙依赖性活性 (PubMed:14570872)。抑制激动剂诱导的细胞内钙信号传导 (PubMed:15980432)。增强电压依赖性P/Q型钙通道的失活，且不支持其钙依赖性易化 (PubMed:11865310)。通过与CACNA1C C末端结构域中钙调蛋白相同位点的结合，引起L型钙通道的钙依赖性易化并抑制其失活，但对通道功能产生相反的影响 (PubMed:15140941)。抑制CACNA1D的钙依赖性失活 (By similarity)。抑制TRPC5通道 (PubMed:15895247)。防止NMDA受体诱导的细胞变性。视网膜光信号正常传递所必需 (By similarity)。 {ECO:0000250|UniProtKB:O88751, ECO:0000250|UniProtKB:Q9JLK7, ECO:0000269|PubMed:11865310, ECO:0000269|PubMed:14570872, ECO:0000269|PubMed:15140941, ECO:0000269|PubMed:15895247, ECO:0000269|PubMed:15980432}.
组织特异性
Retina and brain. Somatodendritic compartment of neurons. Calbrain was found exclusively in brain where it is abundant in the hippocampus, habenular area in the epithalamus and in the cerebellum.
亚细胞定位
Cytoplasm, cytoskeleton
关键词