BRMS1 Q9HCU9

乳腺癌转移抑制蛋白1

功能描述

转录抑制因子。通过促进RELA在'Lys-310'位的去乙酰化，下调NF-kappa-B的转录激活。促进HDAC1结合到启动子区域。下调由NF-kappa-B控制的抗凋亡基因的表达。促进与基质粘附不足的细胞发生凋亡，该过程称为失巢凋亡(anoikis)，从而可能抑制转移。可能是乳腺癌中转移抑制的介导因子。 {ECO:0000269|PubMed:14581478, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:20830743}.

组织特异性

Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies.

亚细胞定位

Nucleus. Cytoplasm. Note=Predominantly nuclear.