BRDT Q58F21

含溴结构域睾丸特异性蛋白 (癌/睾丸抗原9) (CT9) (RING3样蛋白)

功能描述

睾丸特异性染色质蛋白，特异性结合在 'Lys-5' 和 'Lys-8' 乙酰化的组蛋白 H4（分别为 H4K5ac 和 H4K8ac），并在精子发生中发挥关键作用 (PubMed:22464331, PubMed:22901802)。晚期粗线期精母细胞所必需：通过结合特定减数分裂和减数分裂后基因启动子处的乙酰化组蛋白，在减数分裂和减数分裂后细胞中发挥作用，促进其在适当时间激活 (PubMed:22901802)。在精子发生的减数分裂后阶段，结合高乙酰化组蛋白并参与其从 DNA 的一般性移除 (PubMed:22901802)。还识别并结合一部分丁酰化组蛋白：能够结合在 'Lys-8' 丁酰化的组蛋白 H4 (H4K8ac)，但不能结合在 'Lys-5' 丁酰化的 H4 (H4K5ac) (By similarity)。还作为粗线期精母细胞和圆形精子细胞中剪接机制的组分，并参与减数分裂后精子细胞中特定 mRNA 的 3'-UTR 截短 (By similarity)。染色中心组织所必需，该结构由着丝粒周围异染色质组成。 {ECO:0000250|UniProtKB:Q91Y44, ECO:0000269|PubMed:15647849, ECO:0000269|PubMed:22464331, ECO:0000269|PubMed:22901802, ECO:0000269|PubMed:9367677}。

组织特异性

Testis-specific. A 3-fold higher expression is seen in adult testis than in embryo testis. Expression seems to be correlated with histone H4 hyperacetylation during the haploid phase of spermatogenesis (spermiogenesis). No expression, or very low expression is seen in patients' testes with abnormal spermatogenesis. Expressed in cancers such as non-small cell lung cancer and squamous cell carcinomas of the head and neck as well as of esophagus, but not in melanoma or in cancers of the colon, breast, kidney and bladder.

亚细胞定位

Nucleus