BPIFA1 Q9NP55

BPI折叠包含家族A成员1 (肺特异性蛋白X) (鼻咽癌相关蛋白) (腭肺鼻上皮克隆蛋白) (上呼吸道分泌蛋白) (短PLUNC1) (SPLUNC1) (气管上皮富集蛋白) (Von Ebner蛋白Hl)

功能描述

脂质结合蛋白，对表面活性剂磷脂双棕榈酰磷脂酰胆碱 (DPPC) 具有高度特异性 (PubMed:25223608)。在上呼吸道的先天免疫反应中发挥作用 (PubMed:23132494, PubMed:23499554)。降低气道上皮分泌物中的表面张力，并抑制革兰氏阴性病原菌（如铜绿假单胞菌和肺炎克雷伯菌）形成生物膜 (PubMed:23132494, PubMed:23499554, PubMed:27145151)。负向调节 SCNN1G 的蛋白水解切割，该事件是上皮钠通道 (ENaC) 激活所必需的，从而有助于气道表面液体稳态和粘液的正常清除 (PubMed:24043776, PubMed:24124190)。在暴露于刺激物后的气道炎症反应中发挥作用 (PubMed:11425234)。可能吸引巨噬细胞和中性粒细胞 (PubMed:23132494)。 {ECO:0000269|PubMed:11425234, ECO:0000269|PubMed:23132494, ECO:0000269|PubMed:23499554, ECO:0000269|PubMed:24043776, ECO:0000269|PubMed:24124190, ECO:0000269|PubMed:25223608, ECO:0000269|PubMed:27145151}。

组织特异性

Highly expressed in lung, upper airways and nasopharyngeal regions, including trachea and nasal epithelium (at protein level) (PubMed:11018263, PubMed:11251963, PubMed:11425234, PubMed:12409287, PubMed:26559477). Specifically expressed in the secretory ducts and submucosal glands of tracheobronchial tissues (at protein level) (PubMed:11425234, PubMed:12409287). Also expressed in the eye where it is detected in lacrimal gland, eyelid, conjunctiva and cornea (at protein level) (PubMed:26559477). Specifically localizes to epithelial cell layers in cornea, eyelid (basal epithelium) and conjunctiva (at protein level) (PubMed:26559477). Detected within acinar cells and ducts in the lacrimal and Meibomian glands (at protein level) (PubMed:26559477). In lung, shows highest expression in the trachea and progressive decrease from proximal (bronchial) to distal (bronchiolar) airways (PubMed:12409287). Also expressed in lung cancers and some other types of cancer (PubMed:11251963).

亚细胞定位

Secreted