BNC1 Q01954

锌指蛋白basonuclin-1

功能描述

转录激活因子 (By similarity)。可能参与鳞状上皮和毛囊中角质形成细胞终末分化的调节 (PubMed:8034748)。精子发生维持所必需 (By similarity)。参与卵母细胞成熟的正调节，可能通过控制BMP15水平和调节AKT信号级联反应发挥作用 (PubMed:30010909)。也可能在胚胎早期发育中发挥作用 (By similarity)。 {ECO:0000250|UniProtKB:O35914, ECO:0000269|PubMed:30010909, ECO:0000269|PubMed:8034748}。

组织特异性

In epidermis, primarily detected in cells of the basal or immediately suprabasal layers (at protein level) (PubMed:16891417). In hair follicles, mainly expressed in the outer root sheath (at protein level) (PubMed:8034748). Expressed in epidermis, testis and foreskin, and to a lower extent in thymus, spleen, mammary glands, placenta, brain and heart (PubMed:9687312). Expressed in the ovary, notably in oocytes (PubMed:30010909).

亚细胞定位

Nucleus