BLCAP P62952

凋亡诱导因子BLCAP (膀胱癌10 kDa蛋白) (Bc10) (膀胱癌相关蛋白)

功能描述

作为一种肿瘤抑制因子；通过RB1依赖性以及p53/TP53和NF-kappa-B非依赖性机制诱导G(1)/S检查点的生长停滞和细胞凋亡 (PubMed:16675915, PubMed:17031575, PubMed:21844121, PubMed:26986503)。调节参与增殖、细胞周期和凋亡调控的基因表达 (PubMed:17031575, PubMed:21844121, PubMed:26986503)。 {ECO:0000269|PubMed:16675915, ECO:0000269|PubMed:17031575, ECO:0000269|PubMed:21844121, ECO:0000269|PubMed:26986503}。

组织特异性

Cervical tissues (at protein level) (PubMed:22969892). Urothelium (at protein level) (PubMed:19783793, PubMed:29190807). Endothelial cells of urinary bladder vessels (at protein level) (PubMed:19783793). Urinary bladder stromal cells (at protein level) (PubMed:19783793). Cervical tissues (PubMed:16675915). Kidney (PubMed:11072240). Ubiquitous (PubMed:19908260).

亚细胞定位

Cytoplasm