Bcl-2样蛋白11 (Bcl2-L-11) (Bcl2相互作用细胞死亡介导因子)
Bcl-2样蛋白11 (Bcl2-L-11) (Bcl2相互作用细胞死亡介导因子)
O43521功能描述
诱导细胞凋亡和失巢凋亡。Isoform BimL比isoform BimEL效力更强。Isoform Bim-alpha1、isoform Bim-alpha2和isoform Bim-alpha3诱导细胞凋亡，尽管效力弱于isoform BimEL、isoform BimL和isoform BimS。Isoform Bim-gamma诱导细胞凋亡。Isoform Bim-alpha3诱导细胞凋亡可能通过caspase介导的途径。Isoform BimAC和isoform BimABC缺乏诱导细胞凋亡的能力。 {ECO:0000269|PubMed:11997495, ECO:0000269|PubMed:15486195, ECO:0000269|PubMed:15661735, ECO:0000269|PubMed:9430630}。
组织特异性
Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are widely expressed with tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney.
亚细胞定位
Endomembrane system
关键词