BCL2A1 Q16548

Bcl-2相关蛋白A1 (Bcl-2样蛋白5) (Bcl2-L-5) (造血特异性早期反应蛋白) (BFL-1蛋白) (GRS蛋白)

功能描述

延缓由IL-3剥夺诱导的细胞凋亡。可能在造血细胞对外部信号的响应及感染期间维持内皮细胞存活中发挥作用 (By similarity)。能抑制乳腺上皮细胞系HC11中由血清饥饿诱导的细胞凋亡 (By similarity)。 {ECO:0000250, ECO:0000250|UniProtKB:Q07440}。

组织特异性

Seems to be restricted to the hematopoietic compartment. Expressed in peripheral blood, spleen, and bone marrow, at moderate levels in lung, small intestine and testis, at a minimal levels in other tissues. Also found in vascular smooth muscle cells and hematopoietic malignancies.

亚细胞定位

Cytoplasm