含BAR/IMD域接头蛋白2 (脑特异性血管生成抑制剂1相关蛋白2) (BAI相关蛋白2) (BAI1相关蛋白2) (蛋白BAP2) (Fas配体相关因子3) (FLAF3) (胰岛素受体底物p53/p58) (IRS-58) (IRSp53/58) (53 kDa胰岛素受体底物蛋白) (IRSp53) (胰岛素受体底物p53)
含BAR/IMD域接头蛋白2 (脑特异性血管生成抑制剂1相关蛋白2) (BAI相关蛋白2) (BAI1相关蛋白2) (蛋白BAP2) (Fas配体相关因子3) (FLAF3) (胰岛素受体底物p53/p58) (IRS-58) (IRSp53/58) (53 kDa胰岛素受体底物蛋白) (IRSp53) (胰岛素受体底物p53)
Q9UQB8功能描述
连接膜结合小G蛋白与细胞质效应蛋白的衔接蛋白。为CDC42介导的肌动蛋白细胞骨架重组和RAC1介导的膜皱褶所必需。参与WASF家族成员和Arp2/3复合物对肌动蛋白细胞骨架的调节。在神经突生长中起作用。与ENAH协同作用促进丝状伪足形成。在细菌感染应答的肌动蛋白细胞骨架重组中起作用。与EPS8结合时参与肌动蛋白捆绑，促进丝状伪足突起。 {ECO:0000269|PubMed:11130076, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:14752106, ECO:0000269|PubMed:17115031, ECO:0000269|PubMed:19366662}.
组织特异性
Isoform 1 and isoform 4 are expressed almost exclusively in brain. Isoform 4 is barely detectable in placenta, prostate and testis. A short isoform is ubiquitous, with the highest expression in liver, prostate, testis and placenta.
亚细胞定位
Cytoplasm. Membrane; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Cytoplasm, cytoskeleton. Note=Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.
关键词