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B3GNT8 Q7Z7M8

N-乙酰乳糖胺苷β-1,3-N-乙酰氨基葡萄糖转移酶8 (EC 2.4.1.149) (UDP-GlcNAc:betaGal β-1,3-N-乙酰氨基葡萄糖转移酶8) (BGnT-8) (β-1,3-Gn-T8) (β-1,3-N-乙酰氨基葡萄糖转移酶8) (Beta3Gn-T8)

蛋白质信息 (UniProt)

N-乙酰乳糖胺苷β-1,3-N-乙酰氨基葡萄糖转移酶8 (EC 2.4.1.149) (UDP-GlcNAc:betaGal β-1,3-N-乙酰氨基葡萄糖转移酶8) (BGnT-8) (β-1,3-Gn-T8) (β-1,3-N-乙酰氨基葡萄糖转移酶8) (Beta3Gn-T8)

Q7Z7M8

功能描述

β-1,3-N-乙酰氨基葡萄糖转移酶,在多天线N-聚糖特定分支结构的延伸中发挥作用。对四天线N-聚糖和2,6三天线聚糖具有强活性。{ECO:0000269|PubMed:15620693, ECO:0000269|PubMed:15917431, ECO:0000269|PubMed:18826941}。

组织特异性

Highly expressed in small intestine, pancreas, spleen, bone marrow, lung, throat, and ileum, and weakly in fetal brain, cerebellum, heart, liver, tongue, breast, uteri, and testis. Not detected in colon. Differentially expressed in human tumor cell lines.

亚细胞定位

Golgi apparatus membrane

关键词

Glycoprotein Glycosyltransferase Golgi apparatus Membrane Proteomics identification Reference proteome Signal-anchor Transferase Transmembrane Transmembrane helix