共济失调蛋白-2 (脊髓小脑性共济失调2型蛋白) (三核苷酸重复序列包含基因13蛋白)
共济失调蛋白-2 (脊髓小脑性共济失调2型蛋白) (三核苷酸重复序列包含基因13蛋白)
Q99700功能描述
参与EGFR运输，在质膜处作为内吞EGFR内化的负调控因子。 {ECO:0000269|PubMed:18602463}。
组织特异性
Expressed in the brain, heart, liver, skeletal muscle, pancreas and placenta. Isoform 1 is predominant in the brain and spinal cord. Isoform 4 is more abundant in the cerebellum. In the brain, broadly expressed in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus.
亚细胞定位
Cytoplasm
关键词