铜转运ATP酶 2 (EC 7.2.2.8) (铜泵 2) (Wilson病相关蛋白) [裂解为: WND/140 kDa]
铜转运ATP酶 2 (EC 7.2.2.8) (铜泵 2) (Wilson病相关蛋白) [裂解为: WND/140 kDa]
P35670功能描述
铜离子跨膜转运蛋白，参与将铜转运出细胞的过程。它参与肝脏中的铜稳态，在铜过载时，确保铜从肝细胞外排到胆汁中。 {ECO:0000269|PubMed:18203200, ECO:0000269|PubMed:22240481, ECO:0000269|PubMed:24706876, ECO:0000269|PubMed:26004889}.
组织特异性
Most abundant in liver and kidney and also found in brain. Isoform 2 is expressed in brain but not in liver. The cleaved form WND/140 kDa is found in liver cell lines and other tissues.
亚细胞定位
Golgi apparatus, trans-Golgi network membrane
关键词