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ATP6V1E1 P36543

V型质子ATP酶亚基E 1 (V-ATPase subunit E 1) (V-ATPase 31 kDa亚基) (p31) (液泡质子泵亚基E 1)

蛋白质信息 (UniProt)

V型质子ATP酶亚基E 1 (V-ATPase subunit E 1) (V-ATPase 31 kDa亚基) (p31) (液泡质子泵亚基E 1)

P36543

功能描述

液泡(H+)-ATPase (V-ATPase) V1复合物的亚基,该酶是一种多亚基酶,由水解ATP的外周复合物(V1)和转运质子的膜整合复合物(V0)组成 (PubMed:32001091, PubMed:33065002)。V-ATPase负责酸化并维持细胞内区室的pH,在某些细胞类型中,其靶向质膜,负责酸化细胞外环境 (PubMed:32001091)。 {ECO:0000269|PubMed:33065002, ECO:0000303|PubMed:32001091}。

组织特异性

Kidney; localizes to early distal nephron, encompassing thick ascending limbs and distal convoluted tubules (at protein level) (PubMed:29993276). Ubiquitous (PubMed:12036578). High expression in the skin (PubMed:28065471).

亚细胞定位

Apical cell membrane

关键词

3D-structure Acetylation Alternative splicing Cell membrane Cytoplasmic vesicle Direct protein sequencing Disease variant Hydrogen ion transport Ion transport Membrane