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ATP2B4 P23634

质膜钙转运ATP酶 4 (PMCA4) (EC 7.2.2.10) (基质重塑相关蛋白 1) (质膜钙ATP酶亚型 4) (质膜钙泵亚型 4)

蛋白质信息 (UniProt)

质膜钙转运ATP酶 4 (PMCA4) (EC 7.2.2.10) (基质重塑相关蛋白 1) (质膜钙ATP酶亚型 4) (质膜钙泵亚型 4)

P23634

功能描述

钙/钙调蛋白调节和镁依赖性enzyme,催化ATP水解并伴随钙转运出细胞 (PubMed:8530416)。通过调节精子细胞钙稳态,可能在精子运动中发挥作用 (By similarity)。 {ECO:0000250|UniProtKB:Q6Q477, ECO:0000269|PubMed:8530416}。

组织特异性

Isoform XB is the most abundant isoform and is expressed ubiquitously. Isoforms containing segment Z have only been detected in heart, while isoforms containing segment a have been found in heart, stomach and brain cortex.

亚细胞定位

Cell membrane

关键词

3D-structure Alternative splicing ATP-binding Calcium Calcium transport Calmodulin-binding Cell membrane Cell projection Cilium Direct protein sequencing