ATP13A2 Q9NQ11

多胺转运ATP酶 13A2 (EC 7.6.2.-)

功能描述

作为一种ATP酶，起溶酶体多胺外排蛋白的作用，对精胺具有高亲和力 (PubMed:31996848)。同时也促进细胞对多胺的摄取，并保护细胞免受多胺毒性影响 (PubMed:31996848)。在细胞内阳离子稳态和神经元完整性维持中发挥作用 (PubMed:22186024)。有助于细胞锌稳态 (PubMed:24603074)。赋予细胞针对Mn(2+)和Zn(2+)毒性以及线粒体应激的保护作用 (PubMed:26134396)。是溶酶体和线粒体正常维持所必需的 (PubMed:22296644, PubMed:28137957)。通过在转录和翻译后水平控制SYT11的表达来调节自噬-溶酶体途径 (PubMed:27278822)。促进去乙酰化酶HDAC6募集至溶酶体以使CTTN去乙酰化，从而导致肌动蛋白聚合，促进自噬体-溶酶体融合并完成自噬 (PubMed:30538141)。促进外泌体的分泌以及通过外泌体分泌SCNA (PubMed:24603074, PubMed:25392495)。在脂质稳态中发挥作用 (PubMed:31132336)。 {ECO:0000269|PubMed:22186024, ECO:0000269|PubMed:22296644, ECO:0000269|PubMed:24603074, ECO:0000269|PubMed:25392495, ECO:0000269|PubMed:26134396, ECO:0000269|PubMed:27278822, ECO:0000269|PubMed:28137957, ECO:0000269|PubMed:30538141, ECO:0000269|PubMed:31132336, ECO:0000269|PubMed:31996848}。

组织特异性

Expressed in brain; protein levels are markedly increased in brain from subjects with Parkinson disease and subjects with dementia with Lewy bodies. Detected in pyramidal neurons located throughout the cingulate cortex (at protein level). In the substantia nigra, it is found in neuromelanin-positive dopaminergic neurons (at protein level).

亚细胞定位

Lysosome membrane