钾转运ATP酶α链2 (HK alpha 2) (非胃H(+)/K(+) ATPase亚基α) (EC 7.2.2.19) (非胃Na(+)/K(+) ATPase亚基α) (EC 7.2.2.13) (质子泵) (钠泵)
钾转运ATP酶α链2 (HK alpha 2) (非胃H(+)/K(+) ATPase亚基α) (EC 7.2.2.19) (非胃Na(+)/K(+) ATPase亚基α) (EC 7.2.2.13) (质子泵) (钠泵)
P54707功能描述
H(+)/K(+) ATPase和/或Na(+)/K(+) ATPase泵的催化亚基，该泵在上皮细胞顶端膜两侧交换Na(+)和/或H(+)离子以转运K(+)离子。利用ATP作为能量来源，将K(+)离子泵入细胞，同时将Na(+)和/或H(+)离子转运至细胞外区室 (PubMed:11341842, PubMed:7485470, PubMed:8853415, PubMed:9774385)。通过在肾脏和结肠中吸收K(+)离子，参与维持电解质稳态 (By similarity)。在气道上皮中，可能在粘液酸化中发挥主要作用，调节其粘度和清除 (PubMed:29391451)。 {ECO:0000250|UniProtKB:Q9Z1W8, ECO:0000269|PubMed:11341842, ECO:0000269|PubMed:29391451, ECO:0000269|PubMed:7485470, ECO:0000269|PubMed:8853415, ECO:0000269|PubMed:9774385}。
组织特异性
Expressed in airway epithelial cells (at protein level) (PubMed:29391451). Found in skin and kidney. Detected in prostate basal cells (at protein level). Expression is increased in benign prostate hyperplasia and tumor tissues (at protein level).
亚细胞定位
Apical cell membrane
关键词