ATP10B O94823

磷脂转运ATP酶 VB (EC 7.6.2.1) (ATP酶V类10B型) (P4-ATPase翻转酶复合物α亚基ATP10B)

功能描述

P4-ATPase翻转酶复合物的催化成分，催化ATP水解，偶联葡萄糖神经酰胺(GlcCer)从溶酶体膜外叶向内叶的转运。在维持皮层神经元溶酶体膜完整性和功能方面发挥重要作用。 {ECO:0000269|PubMed:32172343}。

组织特异性

Expressed in predominantly in brain structures including medulla oblongata, substantia nigra and basal ganglia. Expressed in the gastrointestinal system with highest levels in the small intestine and colon. Also expressed at low levels in testis and thymus.

亚细胞定位

Late endosome membrane