Atlastin-1 (ATL-1) (EC 3.6.5.-) (脑特异性GTP结合蛋白) (GTP结合蛋白3) (GBP-3) (hGBP3) (鸟苷酸结合蛋白3) (痉挛性截瘫3蛋白A)
Atlastin-1 (ATL-1) (EC 3.6.5.-) (脑特异性GTP结合蛋白) (GTP结合蛋白3) (GBP-3) (hGBP3) (鸟苷酸结合蛋白3) (痉挛性截瘫3蛋白A)
Q8WXF7功能描述
Atlastin-1 (ATL1) 是一种膜锚定的 GTPase，介导内质网 (ER) 膜的 GTP 依赖性融合，维持连续的内质网网络。它促进内质网小管交叉处三向连接的形成 (PubMed:14506257, PubMed:18270207, PubMed:19665976, PubMed:27619977, PubMed:34817557, PubMed:38509071)。邻近内质网小管上的两个 atlastin-1 结合 GTP，并通过 GB1/RHD3 型 G 结构域和 3HB 区域形成松散的同源二聚体。GTP 水解后，3HB 区域收紧，将膜拉在一起以驱动其融合。融合后，同源二聚体在释放无机磷酸 (Pi) 后解离。随后，GDP 解离，将单体重置为准备进行新融合循环的构象 (PubMed:14506257, PubMed:21220294, PubMed:21368113, PubMed:23334294, PubMed:38509071)。可能也直接或间接调节高尔基体的生物发生 (PubMed:17321752)。间接调节轴突发育 (By similarity)。 {ECO:0000250|UniProtKB:Q6PST4, ECO:0000269|PubMed:14506257, ECO:0000269|PubMed:17321752, ECO:0000269|PubMed:18270207, ECO:0000269|PubMed:19665976, ECO:0000269|PubMed:21220294, ECO:0000269|PubMed:21368113, ECO:0000269|PubMed:23334294, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:34817557, ECO:0000269|PubMed:38509071}。
组织特异性
Expressed predominantly in the adult and fetal central nervous system. Measurable expression in all tissues examined, although expression in adult brain is at least 50-fold higher than in other tissues. Detected predominantly in pyramidal neurons in the cerebral cortex and the hippocampus of the brain. Expressed in upper and lower motor neurons (at protein level).
亚细胞定位
Endoplasmic reticulum membrane
关键词