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ASPH Q12797

天冬氨酰/天冬酰胺酰β-羟化酶 (EC 1.14.11.16) (天冬氨酸β-羟化酶) (ASP β-羟化酶) (肽-天冬氨酸β-双加氧酶)

蛋白质信息 (UniProt)

天冬氨酰/天冬酰胺酰β-羟化酶 (EC 1.14.11.16) (天冬氨酸β-羟化酶) (ASP β-羟化酶) (肽-天冬氨酸β-双加氧酶)

Q12797

功能描述

[Isoform 1]: 特异性羟基化多种蛋白质中某些表皮生长因子样(EGF)结构域内的Asp或Asn残基。 {ECO:0000269|PubMed:11773073}.; FUNCTION: [Isoform 8]: 膜结合Ca(2+)感应蛋白,是内质网-质膜连接处的结构组分。Isoform 8调节T细胞中Ca(+2)释放激活的Ca(+2) (CRAC)通道的活性。 {ECO:0000269|PubMed:22586105}.

组织特异性

Isoform 1 is detected in all tissues tested. Isoform 8 is mainly expressed in pancreas, heart, brain, kidney and liver. Isoform 8 is expressed in kidney (at protein level).

亚细胞定位

[Isoform 1]: Endoplasmic reticulum membrane; Single-pass type II membrane protein

关键词

3D-structure Alternative splicing Calcium Dioxygenase Disease variant Disulfide bond Endoplasmic reticulum Glycoprotein Iron Membrane