ARMC9 Q7Z3E5

含LisH结构域蛋白ARMC9 (Armadillo重复序列包含蛋白9) (黑色素瘤/黑素细胞特异性肿瘤抗原KU-MEL-1) (NS21)

蛋白质信息 (UniProt)

含LisH结构域蛋白ARMC9 (Armadillo重复序列包含蛋白9) (黑色素瘤/黑素细胞特异性肿瘤抗原KU-MEL-1) (NS21)

Q7Z3E5

功能描述

参与纤毛发生 (PubMed:32453716)。它是纤毛微管适当乙酰化和多聚谷氨酰化所必需的，并调节纤毛长度 (PubMed:32453716)。作为刺猬 (Hh) 信号通路的正调节因子 (By similarity)。可能参与GLI2和GLI3蛋白在纤毛顶端的运输和/或滞留 (By similarity)。 {ECO:0000250|UniProtKB:E7F187, ECO:0000250|UniProtKB:Q9D2I5, ECO:0000269|PubMed:32453716}。

组织特异性

Strongly expressed in most melanomas and melanocytes. Weakly expressed in the testis.

亚细胞定位

Cytoplasm, cytoskeleton, cilium basal body

关键词

Alternative splicing Cell projection Ciliopathy Cilium biogenesis/degradation Coiled coil Cytoplasm Cytoskeleton Joubert syndrome Phosphoprotein Proteomics identification

外部链接

UniProt: Q7Z3E5

NCBI Gene

GeneCards