Rho鸟嘌呤核苷酸交换因子5 (Ephexin-3) (鸟嘌呤核苷酸调节蛋白TIM) (癌基因TIM) (转化永生化乳腺致癌基因) (p60 TIM)
Rho鸟嘌呤核苷酸交换因子5 (Ephexin-3) (鸟嘌呤核苷酸调节蛋白TIM) (癌基因TIM) (转化永生化乳腺致癌基因) (p60 TIM)
Q12774功能描述
鸟嘌呤核苷酸交换因子，激活Rho GTPases (PubMed:15601624)。强烈激活RHOA (PubMed:15601624)。亦强烈激活RHOB，微弱激活RHOC和RHOG，对RHOD、RHOV、RHOQ或RAC1无作用 (By similarity)。参与细胞形状和肌动蛋白细胞骨架组织的调节 (PubMed:15601624)。通过导致肌动蛋白应力纤维缺失以及膜皱褶和丝状伪足的形成，在肌动蛋白组织中发挥作用 (PubMed:14662653)。SRC诱导的podosome形成所必需 (By similarity)。参与未成熟树突状细胞迁移的正向调节 (By similarity)。 {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}。
组织特异性
Ubiquitously expressed with highest levels in placenta. High levels are also found in colon, kidney, trachea, prostate, liver, pancreas, pituitary gland, thyroid gland and mammary gland. In fetal tissues, expressed at high levels in kidney, lung and liver (PubMed:15601624). Expressed at low levels in lung and heart (PubMed:14662653).
亚细胞定位
Cytoplasm
关键词