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ARHGEF26 Q96DR7

Rho鸟嘌呤核苷酸交换因子26 (含SH3结构域鸟嘌呤交换因子)

蛋白质信息 (UniProt)

Rho鸟嘌呤核苷酸交换因子26 (含SH3结构域鸟嘌呤交换因子)

Q96DR7

功能描述

通过促进GDP交换为GTP激活RhoG GTPase。巨胞饮过程中膜皱褶形成所必需。白细胞跨内皮迁移过程中杯状结构形成所必需。在鼠伤寒沙门氏菌感染的情况下,被SopB激活,从而诱导细胞骨架重排并促进细菌入侵。 {ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17074883, ECO:0000269|PubMed:17875742}.

组织特异性

Isoform 1 is broadly expressed, with highest levels in liver (at protein level). Certain mRNA species appear to be specifically expressed in prostate and liver.

亚细胞定位

Cell projection, ruffle

关键词

3D-structure Alternative splicing Cell projection Guanine-nucleotide releasing factor Phosphoprotein Proteomics identification Reference proteome SH3 domain