Rho鸟嘌呤核苷酸交换因子18 (114 kDa Rho特异性鸟嘌呤核苷酸交换因子) (p114-Rho-GEF) (p114RhoGEF) (Septin相关RhoGEF) (SA-RhoGEF)
Rho鸟嘌呤核苷酸交换因子18 (114 kDa Rho特异性鸟嘌呤核苷酸交换因子) (p114-Rho-GEF) (p114RhoGEF) (Septin相关RhoGEF) (SA-RhoGEF)
Q6ZSZ5功能描述
作为RhoA GTPases的鸟嘌呤核苷酸交换因子(GEF)。其激活诱导肌动蛋白应力纤维的形成。也作为RAC1的GEF，诱导活性氧(ROS)的产生。不作为CDC42的GEF。异三聚体G蛋白的G蛋白β-γ(Gbetagamma)亚基作为激活剂，解释了LPA和其他G蛋白偶联受体激动剂对肌动蛋白应力纤维形成、细胞形态变化和ROS产生的综合效应。上皮细胞中EPB41L4B介导的环状肌动球蛋白带调控所必需的(PubMed:22006950)。 {ECO:0000269|PubMed:11085924, ECO:0000269|PubMed:14512443, ECO:0000269|PubMed:15558029, ECO:0000269|PubMed:22006950, ECO:0000269|PubMed:28132693}。
组织特异性
Expressed in all tissues tested with highest expression in kidney and pancreas. Weakly or not expressed in liver, skeletal muscle and testis. Isoform 1: Expressed in eosinophils (PubMed:29601110). Isoform 2: Expressed in eosinophils (PubMed:29601110). Isoform 3: Expressed in eosinophils (PubMed:29601110). Isoform 4: Not detected in eosinophils (PubMed:29601110).
亚细胞定位
Cytoplasm
关键词