Rho GTP酶激活蛋白24 (Filamin-A相关RhoGAP) (FilGAP) (RAC1和CDC42特异性72 kDa GTP酶激活蛋白) (RC-GAP72) (Rho型GTP酶激活蛋白24) (73 kDa RhoGAP) (肉瘤抗原NY-SAR-88) (p73RhoGAP)
Rho GTP酶激活蛋白24 (Filamin-A相关RhoGAP) (FilGAP) (RAC1和CDC42特异性72 kDa GTP酶激活蛋白) (RC-GAP72) (Rho型GTP酶激活蛋白24) (73 kDa RhoGAP) (肉瘤抗原NY-SAR-88) (p73RhoGAP)
Q8N264功能描述
Rho GTPase激活蛋白，参与细胞极性、细胞形态和细胞骨架组织。作为Rac型GTPase的GTPase激活剂，通过将其转化为非活性的GDP结合状态发挥作用。通过在Rho下游失活Rac来控制肌动蛋白重塑，从而抑制前缘突起并促进细胞回缩以实现细胞极性。在体外能够抑制RAC1和CDC42活性。过表达诱导细胞变圆，伴有肌动蛋白应力纤维的部分或完全破坏，以及膜皱褶、片状伪足和丝状伪足的形成。Isoform 2是一种血管细胞特异性GAP，参与血管生成的调节。 {ECO:0000269|PubMed:15302923, ECO:0000269|PubMed:15611138, ECO:0000269|PubMed:16862148}。
组织特异性
Isoform 1 is widely expressed with a higher level in kidney. Isoform 2 is mainly expressed in endothelial cells.
亚细胞定位
Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction, focal adhesion. Cell projection. Note=Localizes to actin stress fibers. In migrating cells, localizes to membrane lamellae and protusions.
关键词