水通道蛋白-10 (AQP-10) (水甘油通道蛋白-10) (小肠水通道蛋白)
水通道蛋白-10 (AQP-10) (水甘油通道蛋白-10) (小肠水通道蛋白)
Q96PS8功能描述
水甘油通道蛋白形成同源四聚体跨膜通道，每个单体独立地沿着渗透梯度介导甘油和水跨质膜转运 (PubMed:11573934, PubMed:12084581, PubMed:21733844, PubMed:23382902, PubMed:30420639)。也可能对尿素具有通透性 (PubMed:12084581)。在水甘油通道蛋白中，它表现出独特的pH门控甘油转运活性，在酸性pH下活性更高。它极可能在脂肪细胞甘油三酯水解过程中形成的甘油外流以及肠细胞对甘油的摄取中发挥核心作用，因为这两个过程都发生在酸性pH下并受其刺激 (PubMed:11573934, PubMed:23382902, PubMed:30420639)。 {ECO:0000269|PubMed:11573934, ECO:0000269|PubMed:12084581, ECO:0000269|PubMed:21733844, ECO:0000269|PubMed:23382902, ECO:0000269|PubMed:30420639}。
组织特异性
Detected in epithelial cells on villi in the ileum, and also in stomach, jejunum, colon, rectum, white adipose tissue and placenta (at protein level) (PubMed:15221416, PubMed:23382902). Expressed in duodenum and jejunum. Highest expression in absorptive epithelial cells at the tips of villi in the jejunum (PubMed:11573934, PubMed:12084581). Detected in subcutaneous adipose tissue (PubMed:23382902).
亚细胞定位
Apical cell membrane
关键词