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APOL1 O14791

载脂蛋白L1 (载脂蛋白L) (Apo-L) (ApoL) (载脂蛋白L-I) (ApoL-I)

蛋白质信息 (UniProt)

载脂蛋白L1 (载脂蛋白L) (Apo-L) (ApoL) (载脂蛋白L-I) (ApoL-I)

O14791

功能描述

可能在全身的脂质交换和运输中发挥作用。可能参与从外周细胞到肝脏的逆向胆固醇转运。人血清锥虫裂解因子的组分;通过在寄生虫溶酶体膜上形成孔洞并使布氏锥虫对氧化刺激的渗透裂解敏感,从而在杀灭布氏锥虫中发挥关键作用 (PubMed:12621437, PubMed:16020735, PubMed:19997494, PubMed:26645690, PubMed:7723792)。 {ECO:0000269|PubMed:12621437, ECO:0000269|PubMed:16020735, ECO:0000269|PubMed:19997494, ECO:0000269|PubMed:26645690, ECO:0000269|PubMed:7723792}。

组织特异性

Plasma. Found on APOA-I-containing high density lipoprotein (HDL3). Expressed in pancreas, lung, prostate, liver, placenta and spleen.

亚细胞定位

Secreted. Note=Internalized through the endocytic pathway into the lysosomes of Trypanosoma brucei.

关键词

3D-structure Alternative splicing Cholesterol metabolism Direct protein sequencing Disease variant Glycoprotein HDL Lipid metabolism Lipid transport Phosphoprotein