返回首页

APLP1 P51693

淀粉样β前体样蛋白1 (淀粉样β(A4)前体样蛋白1) (淀粉样样蛋白1) (APLP) (APLP-1) [裂解为:C30]

蛋白质信息 (UniProt)

淀粉样β前体样蛋白1 (淀粉样β(A4)前体样蛋白1) (淀粉样样蛋白1) (APLP) (APLP-1) [裂解为:C30]

P51693

功能描述

可能在突触后功能中发挥作用。C端gamma-secretase加工片段ALID1通过结合APBB1 (Fe65)激活转录激活 (By similarity)。通过C端结合偶联JIP信号转导。可能与细胞G-protein信号通路相互作用。可通过结合细胞外基质成分(如heparin和I型collagen)调节神经突生长。 {ECO:0000250}.; FUNCTION: gamma-CTF肽段C30是神经元凋亡的强效增强子。 {ECO:0000250}.

组织特异性

Expressed in the cerebral cortex where it is localized to the postsynaptic density (PSD).

亚细胞定位

Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [C30]: Cytoplasm. Note=C-terminally processed in the Golgi complex.

关键词

3D-structure Alternative splicing Apoptosis Cell adhesion Cell membrane Copper Cytoplasm Disulfide bond Endocytosis Glycoprotein