凋亡抑制因子5 (API-5) (抗凋亡克隆11蛋白) (AAC-11) (细胞迁移诱导基因8蛋白) (成纤维细胞生长因子2相互作用因子) (FIF) (蛋白XAGL)
凋亡抑制因子5 (API-5) (抗凋亡克隆11蛋白) (AAC-11) (细胞迁移诱导基因8蛋白) (成纤维细胞生长因子2相互作用因子) (FIF) (蛋白XAGL)
Q9BZZ5功能描述
抗凋亡因子，可能在蛋白质组装中发挥作用。负调控ACIN1。通过结合ACIN1，抑制ACIN1被CASP3切割以及ACIN1介导的DNA片段化。已知也能有效抑制E2F1诱导的细胞凋亡。其耗竭增强化疗药物的细胞毒作用。 {ECO:0000269|PubMed:10780674, ECO:0000269|PubMed:17112319, ECO:0000269|PubMed:19387494}.
组织特异性
Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in heart, pancreas and placenta. Highly expressed in several cancers. Preferentially expressed in squamous cell carcinoma versus adenocarcinoma in non-small cell lung cancer.
亚细胞定位
Nucleus
关键词