APCDD1蛋白 (腺瘤性结肠息肉病下调蛋白1)
APCDD1蛋白 (腺瘤性结肠息肉病下调蛋白1)
Q8J025功能描述
Wnt信号通路的负调控因子。以细胞自主方式抑制Wnt信号传导，并在beta-catenin上游发挥作用。可能通过与Wnt和LRP蛋白的相互作用起作用。可能在结直肠肿瘤发生中发挥作用。 {ECO:0000269|PubMed:12384519, ECO:0000269|PubMed:20393562}.
组织特异性
Abundantly expressed in heart, pancreas, prostate and ovary. Moderately expressed in lung, liver, kidney, spleen, thymus, colon and peripheral lymphocytes. Abundantly expressed in both the epidermal and dermal compartments of the hair follicle. Present in scalp skin Highly expressed in the hair follicle dermal papilla, the matrix, and the hair shaft (at protein level).
亚细胞定位
Cell membrane
关键词